(This is general information only — always consult a healthcare provider.)
Alcohol interacts with many substances in ways that can be dangerous or life-threatening. The following combinations are ones you should avoid, because mixing them with alcohol can cause serious side effects, weakened breathing, impaired judgment, overdose, or organ stress.
Examples:
Oxycodone, Hydrocodone, Morphine, Fentanyl, Codeine
What can happen:
• Extreme drowsiness
• Slow or stopped breathing
• Loss of consciousness
• Overdose risk increases significantly
Examples:
Alprazolam (Xanax), Diazepam (Valium), Lorazepam (Ativan)
What can happen:
• Severe sedation
• Impaired coordination
• Respiratory depression
• Coma or fatal overdose
Examples:
Zolpidem (Ambien), Eszopiclone, Sedating drugs
What can happen:
• Enhanced sedation
• Confusion, memory issues
• Breathing problems
• Falls and injuries
Examples:
Fluoxetine (Prozac), Sertraline (Zoloft), Citalopram (Celexa)
What can happen:
• Increased drowsiness
• Impaired concentration
• Worsened effects of alcohol
• Possible mood changes
Examples:
Cyclobenzaprine (Flexeril), Carisoprodol (Soma)
What can happen:
• Intensified sedative effects
• Breathing suppression
• Danger when combined with other depressants
Examples:
Quetiapine (Seroquel), Lithium (with caution)
What can happen:
• Heightened sedation
• Imbalance in electrolytes
• Interaction with liver metabolism
Examples:
Beta-blockers, ACE inhibitors
What can happen:
• Lowered blood pressure
• Fainting risk
• Irregular heart rhythm
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